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Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase

2 Apr 2014

Abstract excerpt

The yeast Hsp31 minifamily proteins (Hsp31, Hsp32, Hsp33, Hsp34) belong to the highly conserved DJ-1 superfamily. The human DJ-1 protein is associated with cancer and neurodegenerative disorders, such as Parkinson disease. However, the precise function of human and yeast DJ-1 proteins is unclear. Here we show that the yeast DJ-1 homologs have a role in diauxic-shift (DS), characterized by metabolic reprogramming...

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PMID: 24706893
DOI: 10.1073/pnas.1319221111

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