The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1.

doi:10.18632/aging.100065

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The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1.

Aging - 13 Jul 2009

Heeren Gino, Rinnerthaler Mark, Laun Peter, von Seyerl Phyllis, Kössler Sonja, Klinger Harald, Hager Matthias, Bogengruber Edith, Jarolim Stefanie, Simon-Nobbe Birgit, Schüller Christoph, Carmona-Gutierrez Didac, Breitenbach-Koller Lore, Mück Christoph, Jansen-Dürr Pidder, Criollo Alfredo, Kroemer Guido, Madeo Frank, Breitenbach Michael

Abstract excerpt

Yeast mother cell-specific aging constitutes a model of replicative aging as it occurs in stem cell populations of higher eukaryotes. Here, we present a new long-lived yeast deletion mutation,afo1 (for aging factor one), that confers a 60% increase in replicative lifespan. AFO1/MRPL25 codes for a protein that is contained in the large subunit of the mitochondrial ribosome. Double mutant experiments indicate that...

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PMID: 20157544
DOI: 10.18632/aging.100065
PMCID: PMC2806038

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