Article
Inactivation of the 20S proteasome maturase, Ump1p, leads to the instability of mtDNA in Saccharomyces cerevisiae.
Mutation research - 2 Oct 2009
Malc Ewa, Dzierzbicki Piotr, Kaniak Aneta, Skoneczna Adrianna, Ciesla Zygmunt
Abstract excerpt
The proteasome plays fundamental roles in the removal of oxidized proteins and in normal degradation of short-lived proteins. Increasing evidence suggests that the proteasome may be an important factor in both oxidative stress response and cellular aging. Moreover, it was recently reported that proteasome inhibition leads to mitochondrial dysfunction. In this study, we have investigated whether proteasome...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.