Article
The product of the UTH1 gene, required for Bax-induced cell death in yeast, is involved in the response to rapamycin.
Molecular microbiology - 1 Jan 2003
Camougrand Nadine, Grelaud-Coq Angela, Marza Esther, Priault Muriel, Bessoule Jean-Jacques, Manon Stéphen
Abstract excerpt
A yeast mutant was isolated that was resistant to Bax-induced cell death. It supports a mutation leading to decreased amounts of the protein Uth1p. A strain in which the UTH1 gene is disrupted also exhibits resistance to Bax expression. The absence of Uth1p does not change the mitochondrial localization of Bax, its insertion in the mitochondrial outer membrane or its cytochrome c-releasing activity. On the other...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.