Article
In vivo mutagenicity of arsenite in the livers of gpt delta transgenic mice.
Mutation research. Genetic toxicology and environmental mutagenesis - 15 Jan 2014
Takumi Shota, Aoki Yasunobu, Sano Tomoharu, Suzuki Takehiro, Nohmi Takehiko, Nohara Keiko
Abstract excerpt
While arsenic has been classified as a Group 1 human carcinogen by the International Agency for Research on Cancer (IARC), its mutagenicity has not been fully characterized in experimental animals. The aim of this study was to assess the in vivo mutagenicity of arsenite in C57BL/6J gpt delta mice. Male gpt delta mice were given drinking water containing sodium arsenite for 3 weeks, and the hepatic genome was...
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