Article
Detection of oxidative DNA damage, cell proliferation and in vivo mutagenicity induced by dicyclanil, a non-genotoxic carcinogen, using gpt delta mice.
Mutation research - 1 Sept 2007
Umemura Takashi, Kuroiwa Yuichi, Tasaki Masako, Okamura Toshiya, Ishii Yuji, Kodama Yukio, Nohmi Takehiko, Mitsumori Kunitoshi, Nishikawa Akiyoshi, Hirose Masao
Abstract excerpt
To ascertain whether measurement of possible contributing factors to carcinogenesis concurrently with the transgenic mutation assay is useful to understand the mode of action underlying tumorigenesis of non-genotoxic carcinogens, male and female gpt delta mice were given dicyclanil (DC), a mouse hepatocarcinogen showing all negative results in various genotoxicity tests, at a carcinogenic dose for 13 weeks....
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