Article
DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51.
Nucleic acids research - 1 Jan 2004
Doe Claudette L, Osman Fekret, Dixon Julie, Whitby Matthew C
Abstract excerpt
In budding yeast most Rad51-dependent and -independent recombination depends on Rad52. In contrast, its homologue in fission yeast, Rad22, was assumed to play a less critical role possibly due to functional redundancy with another Rad52-like protein Rti1. We show here that this is not the case. Rad22 like Rad52 plays a central role in recombination being required for both Rhp51-dependent and -independent events....
Topics
- DNA Repair
- DNA, Fungal
- DNA-Binding Proteins
- Endonucleases
- Models, Genetic
- Mutation
- Nucleic Acid Conformation
- Rad51 Recombinase
- Recombination, Genetic
- Repetitive Sequences, Nucleic Acid
- Saccharomyces cerevisiae Proteins