A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man.

doi:10.1101/gad.6.3.454

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Article

A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man.

Genes & development - 1 Mar 1992

Falb D, Maniatis T

Abstract excerpt

The Drosophila melanogaster alcohol dehydrogenase (Adh) gene is expressed in a specific set of tissues during larval development and in adults. Expression in the adult fat body is controlled by the Adh adult enhancer (AAE). Previous studies identified a negative regulatory element in the AAE and a protein that binds specifically to this sequence [adult enhancer factor-1 (AEF-1)]. Here, we show that the...

Topics

Alcohol Dehydrogenase
Animals
Base Sequence
Binding Sites
Biological Evolution
CCAAT-Enhancer-Binding Proteins
DNA
DNA Fingerprinting
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Enhancer Elements, Genetic

Fat Body

Female

Gene Expression

Molecular Sequence Data

Mutation

Nuclear Proteins

Source

Open in PubMed

Identifiers

PMID: 1547943
DOI: 10.1101/gad.6.3.454

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1547943-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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