Purified Drosophila transcription factor, Adh distal factor-1 (Adf-1), binds to sites in several Drosophila promoters and activates transcription.

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Article

Purified Drosophila transcription factor, Adh distal factor-1 (Adf-1), binds to sites in several Drosophila promoters and activates transcription.

The Journal of biological chemistry - 25 Mar 1990

England B P, Heberlein U, Tjian R

Abstract excerpt

Adh distal factor-1 (Adf-1) is a sequence-specific DNA-binding activity originally identified in Drosophila tissue culture cells and embryos. Adf-1 binds to upstream recognition elements in each of the two promoters of the Drosophila alcohol dehydrogenase gene (Adh), and binding of Adf-1 to the Adh distal promoter site activates transcription. We have carried out a mutational analysis of the Adh distal promoter...

Topics

Alcohol Dehydrogenase
Animals
Base Sequence
Cell Nucleus
Chromatography, Affinity
Chromatography, Gel
Chromosome Deletion
Drosophila
Enzyme Activation
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Promoter Regions, Genetic

Protein Binding

Transcription Factors

Transcription, Genetic

Transfection

Source

Open in PubMed

Identifiers

PMID: 2318884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2318884-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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