Article
trans activation of human alcohol dehydrogenase gene expression in hepatoma cells by C/EBP molecules bound in a novel arrangement just 5' and 3' to the TATA box.
Molecular and cellular biology - 1 Sept 1990
Stewart M J, Shean M L, Duester G
Abstract excerpt
A promoter sequence between nucleotide -51 and nucleotide -10 in the human alcohol dehydrogenase gene ADH2 has been shown to bind the transcription factor CCAAT/enhancer-binding protein (C/EBP). A series of 5'-end deletions of the ADH2 promoter was cotransfected with a C/EBP expression plasmid in...
Topics
- Alcohol Dehydrogenase
- CCAAT-Enhancer-Binding Proteins
- Carcinoma, Hepatocellular
- Cell Line
- DNA-Binding Proteins
- Gene Expression Regulation, Enzymologic
- Genes
- Humans
- Liver Neoplasms
- Mutation
- Promoter Regions, Genetic
- Transfection