Article
The role of CCAAT/enhancer-binding protein in the differential transcriptional regulation of a family of human liver alcohol dehydrogenase genes.
The Journal of biological chemistry - 25 Jun 1991
Stewart M J, Shean M L, Paeper B W, Duester G
Abstract excerpt
The transcription factor CCAAT/enhancer-binding protein (C/EBP) was found to selectively trans-activate one member of the human class I alcohol dehydrogenase (ADH) gene family. A comparison of the promoters for the three human class I ADH genes ADH1, ADH2, and ADH3 indicated a very similar patter...
Topics
- Alcohol Dehydrogenase
- Animals
- Base Sequence
- CCAAT-Enhancer-Binding Proteins
- Chloramphenicol O-Acetyltransferase
- DNA
- DNA-Binding Proteins
- Humans
- Liver
- Molecular Sequence Data
- Multigene Family
- Mutagenesis, Site-Directed
- Mutation
- Nuclear Proteins
- Plasmids
- Promoter Regions, Genetic
- Rats
- Sequence Homology, Nucleic Acid