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Article

An enhancer-blocking element regulates the cell-specific expression of alcohol dehydrogenase 7.

Gene - 1 Sept 2014

Jairam Sowmya, Edenberg Howard J

Abstract excerpt

The class IV alcohol dehydrogenase gene ADH7 encodes an enzyme that is involved in ethanol and retinol metabolism. ADH7 is expressed mainly in the upper gastrointestinal tract and not in the liver, the major site of expression of the other closely related ADHs. We identified an intergenic sequence (iA1C), located between ADH7 and ADH1C, that has enhancer-blocking activity in liver-derived HepG2 cells that do not...

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Share to Alcohol Dehydrogenase
Share to CCCTC-Binding Factor
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24971505
DOI: 10.1016/j.gene.2014.06.047
PMCID: PMC4136687

Genes

ADH7
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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