Article
An Ebox element in the proximal Gata4 promoter is required for Gata4 expression in vivo.
PloS one - 1 Jan 2011
Boulende Sab Alain, Bouchard Marie-France, Béland Mélanie, Prud'homme Bruno, Souchkova Ouliana, Viger Robert S, Pilon Nicolas
Abstract excerpt
GATA4 is an essential transcription factor required for the development and function of multiple tissues, including a major role in gonadogenesis. Despite its crucial role, the molecular mechanisms that regulate Gata4 expression in vivo remain poorly understood. We recently found that the Gata4 gene is expressed as multiple transcripts with distinct 5' origins. These co-expressed alternative transcripts are...
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