Article
Ventromedial hypothalamic nucleus-specific enhancer of Ad4BP/SF-1 gene.
Molecular endocrinology (Baltimore, Md.) - 1 Nov 2005
Shima Yuichi, Zubair Mohamad, Ishihara Satoru, Shinohara Yuko, Oka Sanae, Kimura Shioko, Okamoto Shiki, Minokoshi Yasuhiko, Suita Sachiyo, Morohashi Ken-ichirou
Abstract excerpt
Ad4BP/SF-1 [Ad4 binding protein/steroidogenic factor-1 (designated NR5A1)] is a transcription factor essential for animal reproduction. Based on the phenotypes observed in gene-disrupted mice, Ad4BP/SF-1 is thought to be involved in establishment of the hypothalamic-pituitary-gonadal axis. However, the mechanisms underlying tissue-specific expression of Ad4BP/SF-1 are largely unknown. Here, we investigated the...
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