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Article

Targeted deletion of the zebrafish actin-bundling protein L-plastin (lcp1).

PloS one - 1 Jan 2018

Kell Margaret J, Riccio Rachel E, Baumgartner Emily A, Compton Zachary J, Pecorin Paul J, Mitchell Taylor A, Topczewski Jacek, LeClair Elizabeth E

Abstract excerpt

Regulation of the cytoskeleton is essential for cell migration in health and disease. Lymphocyte cytosolic protein 1 (lcp1, also called L-plastin) is a hematopoietic-specific actin-bundling protein that is highly conserved in zebrafish, mice and humans. In addition, L-plastin expression is documented as both a genetic marker and a cellular mechanism contributing to the invasiveness of tumors and transformed cell...

Topics

Alleles
Amino Acid Sequence
Animals
Cloning, Molecular
Clustered Regularly Interspaced Short Palindromic Repeats
Gene Deletion
Humans
Membrane Glycoproteins
Mice
Microfilament Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Amino Acid

Zebrafish

Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29293625
DOI: 10.1371/journal.pone.0190353
PMCID: PMC5749806

Genes

LCP1
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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