Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted deletion of the zebrafish actin-bundling protein L-plastin (lcp1).

PloS one - 1 Jan 2018

Kell Margaret J, Riccio Rachel E, Baumgartner Emily A, Compton Zachary J, Pecorin Paul J, Mitchell Taylor A, Topczewski Jacek, LeClair Elizabeth E

Abstract excerpt

Regulation of the cytoskeleton is essential for cell migration in health and disease. Lymphocyte cytosolic protein 1 (lcp1, also called L-plastin) is a hematopoietic-specific actin-bundling protein that is highly conserved in zebrafish, mice and humans. In addition, L-plastin expression is documented as both a genetic marker and a cellular mechanism contributing to the invasiveness of tumors and transformed cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cloning, Molecular
Share to Clustered Regularly Interspaced Short Palindromic Repeats

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Membrane Glycoproteins

Share to Microfilament Proteins

Share to Sequence Homology, Amino Acid

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29293625
DOI: 10.1371/journal.pone.0190353
PMCID: PMC5749806

Genes

LCP1
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted deletion of the zebrafish actin-bundling protein L-plastin (lcp1).PMID 29293625Read ↗

L-plastin associated syndrome of immune deficiency and hematologic cytopenia.Semantic proximity Read ↗

Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia.Semantic proximity Read ↗

NCKAP1L defects lead to a novel syndrome combining immunodeficiency, lymphoproliferation, and hyperinflammation.Semantic proximity Read ↗

Loss of coactosin-like F-actin binding protein 1 (Cotl1) decreases platelet-mediated osteoclastogenesis and causes osteopetrosis phenotypes in mouseSemantic proximity Read ↗

Characterization of zebrafish merlot/chablis as non-mammalian vertebrate models for severe congenital anemia due to protein 4.1 deficiency.Semantic proximity Read ↗

The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.Semantic proximity Read ↗

B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1Semantic proximity Read ↗

Generation of a Ym1 Deficient Mouse utilising CRISPR-Cas9 in CB6 EmbryosSemantic proximity Read ↗

Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1.Semantic proximity Read ↗

Leukocyte adhesion deficiency in children and Irish setter dogs.Semantic proximity Read ↗

Autosomal recessive hyposegmentation of granulocytes in Australian Shepherd Dogs indicates a role for LMBR1L in myeloid leukocytes.Semantic proximity Read ↗

Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.