Article
Expression by transgenesis of a constitutively active mutant form of the prolactin receptor induces premature abnormal development of the mouse mammary gland and lactation failure.
Biology of reproduction - 1 Mar 2004
Gourdou Isabelle, Paly Jacqueline, Hue-Beauvais Catherine, Pessemesse Laurence, Clark John, Djiane Jean
Abstract excerpt
Prolactin (PRL) initiates signal transduction by inducing homodimerization of PRL receptor (PRL-R). We have previously developed a mutant form of the PRL-R in which a part of the extracellular domain is deleted. This receptor constitutively activates protein gene transcription. We examined the oligomerization of the mutant PRL-R using two differently epitope-tagged receptors in a coimmunoprecipitation assay. It...
Topics
- Animals
- COS Cells
- Dimerization
- Female
- Lactation Disorders
- Mammary Glands, Animal
- Mice
- Mice, Transgenic
- Milk
- Phenotype
- Pregnancy