Article
Pas1 haplotype-dependent genetic predisposition to lung tumorigenesis in rodents: a meta-analysis.
Carcinogenesis - 1 May 2005
Manenti Giacomo, Dragani Tommaso A
Abstract excerpt
Rodent species and strains show wide variations in susceptibility to lung tumorigenesis. In mice, hierarchical clustering of 29 inbred laboratory strains by pulmonary adenoma susceptibility 1 (Pas1) locus polymorphisms separated the strains into either an A/J- or a C57BL/6J-type Pas1 haplotype. A pooled analysis (including >8500 mice) of studies on spontaneous and chemically induced lung tumorigenesis in these...
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