Article
Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism.
Carcinogenesis - 1 Jan 2000
Rojas M, Cascorbi I, Alexandrov K, Kriek E, Auburtin G, Mayer L, Kopp-Schneider A, Roots I, Bartsch H
Abstract excerpt
The modulation of benzo[a]pyrene diolepoxide (BPDE)-DNA adduct levels by polymorphisms in the CYP1A1, GSTM1 and GSTT1 genes was assessed in leukocytes of Caucasian males. Eighty-nine coke oven workers (35 smokers, 36 ex-smokers and 18 non-smokers) were recruited from job categories with different...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Adult
- Cytochrome P-450 CYP1A1
- DNA Adducts
- Genotype
- Glutathione Transferase
- Humans
- Isoenzymes
- Lung Neoplasms
- Male
- Multivariate Analysis
- Occupational Exposure
- Polymorphism, Genetic
- Smoking