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Article

Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers.

Cancer detection and prevention - 1 Jan 1999

Bartsch H, Rojas M, Nair U, Nair J, Alexandrov K

Abstract excerpt

Preventive strategies require identification of cancer-susceptible individuals resulting from combinations of carcinogen exposure, cancer-predisposing genes, and lack of protective factors. To this aim, related to tobacco smoking and chewing (betel quid), we measured PAH-DNA adducts as exposure and susceptibility markers together with genetic polymorphism in drug-metabolizing enzymes related to CYP1A1, GSTM1, and...

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Topics

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Share to 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Share to Cytochrome P-450 CYP1A1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10571654
DOI: 10.1046/j.1525-1500.1999.99055.x

Genes

GSTM1
GSTT1
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers.PMID 10571654Read ↗

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High benzo[a]pyrene diol-epoxide DNA adduct levels in lung and blood cells from individuals with combined CYP1A1 MspI/Msp-GSTM1*0/*0 genotypes.Semantic proximity Read ↗

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Influence of GSTM1 genotypes on anti-BPDE-DNA adduct levels in mononuclear white blood cells of humans exposed to PAH.Semantic proximity Read ↗

Influence of GSTM1, GSTT1, GSTP1, and EPHX gene polymorphisms on DNA adduct level and HPRT mutant frequency in coke-oven workers.Semantic proximity Read ↗

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