Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Virally Mediated Overexpression of Glial-Derived Neurotrophic Factor Elicits Age- and Dose-Dependent Neuronal Toxicity and Hearing Loss.

Human gene therapy - 1 Jan 2019

Akil Omar, Blits Bas, Lustig Lawrence R, Leake Patricia A

Abstract excerpt

Contemporary cochlear implants (CI) are generally very effective for remediation of severe to profound sensorineural hearing loss, but outcomes are still highly variable. Auditory nerve survival is likely one of the major factors underlying this variability. Neurotrophin therapy therefore has been proposed for CI recipients, with the goal of improving outcomes by promoting improved survival of cochlear spiral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cochlea
Share to Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Genetic Therapy

Share to Genetic Vectors

Share to Glial Cell Line-Derived Neurotrophic Factor

Share to Hearing Loss

Share to Neurons

Source

Open in PubMed Open full text

Identifiers

PMID: 30183384
DOI: 10.1089/hum.2018.028
PMCID: PMC6343370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Virally Mediated Overexpression of Glial-Derived Neurotrophic Factor Elicits Age- and Dose-Dependent Neuronal Toxicity and Hearing Loss.PMID 30183384Read ↗

Molecular Aspects of the Development and Function of Auditory Neurons.Semantic proximity Read ↗

BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice.Semantic proximity Read ↗

Progressive hearing loss in mice carrying a mutation in the p75 gene.Semantic proximity Read ↗

Adeno-associated viral vector administration to the inner ear and phenotype evaluation in a mouse model of hearing loss.Semantic proximity Read ↗

Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear.Semantic proximity Read ↗

Gene therapy for hearing loss.Semantic proximity Read ↗

Gene Therapy for Inherited Hearing Loss: Updates and Chal-lengesSemantic proximity Read ↗

Gene Expression in the Mammalian Cochlea: A Study of Multiple Vector SystemsSemantic proximity Read ↗

In Vivo Delivery of Recombinant Viruses to the Fetal Murine Cochlea: Transduction Characteristics and Long-Term Effects on Auditory FunctionSemantic proximity Read ↗

Beyond Excitotoxicity: Glutamate-Independent Mechanisms Underlie Noise-Induced Synaptopathy and Compromise Gene Therapy for Hereditary DeafnessSemantic proximity Read ↗

Rescue of auditory function by a single administration of AAV-TMPRSS3 gene therapy in aged mice of human recessive deafness DFNB8Semantic proximity Read ↗

Gene therapy for deafness.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.