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Article

In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear.

PLoS genetics - 1 Jan 2013

Del Rio Tony, Nishitani Allison M, Yu Wei-Ming, Goodrich Lisa V

Abstract excerpt

Lrig proteins are conserved transmembrane proteins that modulate a variety of signaling pathways from worm to humans. In mammals, there are three family members - Lrig1, Lrig2, and Lrig3--that are defined by closely related extracellular domains with a similar arrangement of leucine rich repeats and immunoglobulin domains. However, the intracellular domains show little homology. Lrig1 inhibits EGF signaling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Glycoproteins

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Share to Receptor, ErbB-2

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Source

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Identifiers

PMID: 24086156
DOI: 10.1371/journal.pgen.1003824
PMCID: PMC3784559

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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