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Article

Neurod1 regulates survival and formation of connections in mouse ear and brain.

Cell and tissue research - 1 Jul 2010

Jahan Israt, Kersigo Jennifer, Pan Ning, Fritzsch Bernd

Abstract excerpt

The developing sensory neurons of the mammalian ear require two sequentially activated bHLH genes, Neurog1 and Neurod1, for their development. Neurons never develop in Neurog1 null mice, and most neurons die in Neurod1 null mutants, a gene upregulated by Neurog1. The surviving neurons of Neurod1 null mice are incompletely characterized in postnatal mice because of the early lethality of mutants and the possible...

Topics

Animals
Basic Helix-Loop-Helix Transcription Factors
Brain
Cell Survival
Cochlea
Ear, Inner
Gene Expression Regulation
Mice
Mice, Knockout
Models, Biological
Nerve Net

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons, Afferent

Phenotype

Vestibule, Labyrinth

Source

Open in PubMed Open full text

Identifiers

PMID: 20512592
DOI: 10.1007/s00441-010-0984-6
PMCID: PMC3657738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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