Article
Targeted deletion of Sox10 by Wnt1-cre defects neuronal migration and projection in the mouse inner ear.
PloS one - 1 Jan 2014
Mao YanYan, Reiprich Simone, Wegner Michael, Fritzsch Bernd
Abstract excerpt
Sensory nerves of the brainstem are mostly composed of placode-derived neurons, neural crest-derived neurons and neural crest-derived Schwann cells. This mixed origin of cells has made it difficult to dissect interdependence for fiber guidance. Inner ear-derived neurons are known to connect to the brain after delayed loss of Schwann cells in ErbB2 mutants. However, the ErbB2 mutant related alterations in the ear...
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