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The integrated stress response mediates type I interferon driven necrosis in Mycobacterium tuberculosis granulomas

2018-12-19

Abstract excerpt

Necrosis in the tuberculous granuloma is a hallmark of tuberculosis that enables pathogen survival and transmission. Susceptibility to tuberculosis and several other intracellular bacteria is controlled by a mouse genetic locus, sst1, and mice carrying the sst1-suscepible (sst1S) genotype develop necrotic inflammatory lung lesions, similar to human TB granulomas. Our previous work established that increased diseas...

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Literature Corpus work
596de9ed-63f3-54d6-a8a6-358530f5838b
DOI
10.1101/499467
Open publication

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The integrated stress response mediates type I interferon driven necrosis in Mycobacterium tuberculosis granulomasDOI 10.1101/499467
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