Article
IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2004
Alba Aurora, Puertas M Carmen, Carrillo Jorge, Planas Raquel, Ampudia Rosa, Pastor Xavier, Bosch Fatima, Pujol-Borrell Ricardo, Verdaguer Joan, Vives-Pi Marta
Abstract excerpt
Genetic and environmental factors are decisive in the etiology of type 1 diabetes. Viruses have been proposed as a triggering environmental event and some evidences have been reported: type I IFNs exist in the pancreata of diabetic patients and transgenic mice expressing these cytokines in beta cells develop diabetes. To determine the role of IFNbeta in diabetes, we studied transgenic mice expressing human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.