Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bridging mice to men: using HLA transgenic mice to enhance the future prediction and prevention of autoimmune type 1 diabetes in humans.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010

Serreze David V, Niens Marijke, Kulik John, Dilorenzo Teresa P

Abstract excerpt

Similar to the vast majority of cases in humans, the development of type 1 diabetes (T1D) in the NOD mouse model is due to T-cell mediated autoimmune destruction of insulin-producing pancreatic beta cells. Particular major histocompatibility complex (MHC) haplotypes (designated HLA in humans and H2 in mice) provide the primary genetic risk factor for T1D development. It has long been appreciated that within the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 1
Share to Glucose-6-Phosphatase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA Antigens

Share to Insulin

Share to Mice, Inbred NOD

Share to Mice, Transgenic

Share to Proteins

Share to Transgenes

Source

Identifiers

PMID: 20012396
DOI: 10.1007/978-1-60761-058-8_8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bridging mice to men: using HLA transgenic mice to enhance the future prediction and prevention of autoimmune type 1 diabetes in humans.PMID 20012396Read ↗

Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes.Semantic proximity Read ↗

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.Semantic proximity Read ↗

Human Risk Allele HLA-DRB1*0405 Predisposes Class II Transgenic Ab0 NOD Mice to Autoimmune PancreatitisSemantic proximity Read ↗

Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes.Semantic proximity Read ↗

Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse.Semantic proximity Read ↗

An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients.Semantic proximity Read ↗

Understanding autoimmune diabetes: insights from mouse models.Semantic proximity Read ↗

HLA class II transgenic mice as models of human diseasesSemantic proximity Read ↗

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes.Semantic proximity Read ↗

Type 1 diabetes genes and pathways shared by humans and NOD mice.Semantic proximity Read ↗

Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse.Semantic proximity Read ↗

The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.