Article
Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection.
Journal of hepatology - 1 Oct 2004
Mueller Tobias, Mas-Marques Andreas, Sarrazin Christoph, Wiese Manfred, Halangk Juliane, Witt Heiko, Ahlenstiel Golo, Spengler Ulrich, Goebel Uwe, Wiedenmann Bertram, Schreier Eckart, Berg Thomas
Abstract excerpt
BACKGROUND/AIMS: Interleukin-12 (IL-12) governs the Th1-type immune response, affecting the spontaneous and treatment-induced recovery from HCV-infection. We investigated whether the IL12B polymorphisms within the promoter region (4 bp insertion/deletion) and the 3'-UTR (1188-A/C), which have bee...
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