Article
Prevalence of Thymine--Adenine Dinucleotide Repeat, IL28B and IFNL4 in Thai Population and Correlation with Spontaneous Clearance and Treatment Outcome of Hepatitis C Infection.
PloS one - 1 Jan 2015
Thong Vo Duy, Wasitthankasem Rujipat, Tangkijvanich Pisit, Vongpunsawad Sompong, Poovorawan Yong
Abstract excerpt
BACKGROUND: The interleukin-28B (IL28B) gene polymorphism is a strong baseline predictor of sustained virological response (SVR) in hepatitis C virus (HCV) treatment. The length of thymine--adenine dinucleotide repeats, or (TA)n, in the regulatory region of IL28B can affect interferon transcription. In order to determine predictive values in HCV infection, we explored the correlation among factors including (TA)n...
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