Article
Hepatitis C Virus-Infected Responders and Relapsers to Treatment Show Similar Genetic Profiles of IL28B and IL10 Single Nucleotide Polymorphisms.
BioMed research international - 1 Jan 2018
de Souza Suiane Lima, Vidal Luãnna Liebscher, Ramos Juliene, Cardoso Cynthia Chester, Coelho Henrique Sérgio Moraes, Villela-Nogueira Cristiane Alves, Perez Renata de Mello, Soares Marcelo Alves, Santos André Felipe
Abstract excerpt
Genotype 1 of hepatitis C virus (HCV) is the most prevalent worldwide. Pegylated-interferon and ribavirin therapy is still used in the developing world but has less efficiency in this genotype. Single nucleotide polymorphisms (SNPs) rs12979860 and rs8099917 (IL28B) and rs1800896, rs1800871, and rs1800872 (IL10) are related to treatment outcome, but previous studies clustered nonresponse and relapse patients. The...