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Article

Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline.

Therapeutic drug monitoring - 1 Feb 1992

Baumann P, Meyer J W, Amey M, Baettig D, Bryois C, Jonzier-Perey M, Koeb L, Monney C, Woggon B

Abstract excerpt

The metabolism of most tricyclic antidepressants and some phenothiazine neuroleptics is under the genetic control of hepatic cytochrome P-450IID6, which also regulates the metabolism of dextromethorphan. This study investigated the effect of treatment with amitriptyline or thioridazine on testing for genetically regulated efficiency of the metabolism of dextromethorphan and mephenytoin. One group of 33 patients...

Topics

Adult
Amitriptyline
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Dextromethorphan
Female
Humans
Liver
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mephenytoin

Middle Aged

Mixed Function Oxygenases

Phenotype

Thioridazine

Source

Identifiers

PMID: 1546384
DOI: 10.1097/00007691-199202000-00001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1546384-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline.PMID 1546384Read ↗

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