Influence of amiodarone on genetically determined drug metabolism in humans.

doi:10.1038/clpt.1991.135

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Article

Influence of amiodarone on genetically determined drug metabolism in humans.

Clinical pharmacology and therapeutics - 1 Sept 1991

Funck-Brentano C, Jacqz-Aigrain E, Leenhardt A, Roux A, Poirier J M, Jaillon P

Abstract excerpt

Amiodarone has been shown to interact with the nongenetically determined hepatic elimination of several drugs, including phenytoin and digoxin. Its influence on genetically determined metabolic pathways has not been studied in humans. We examined the effects of oral amiodarone therapy on the gene...

Topics

Adult
Aged
Aged, 80 and over
Amiodarone
Arrhythmias, Cardiac
Arylamine N-Acetyltransferase
Cytochrome P-450 Enzyme System
Dextromethorphan
Female
Humans
Isoniazid
Liver
Male
Mephenytoin
Middle Aged
Phenotype

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