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Article

Influence of amiodarone on genetically determined drug metabolism in humans.

Clinical pharmacology and therapeutics - 1 Sept 1991

Funck-Brentano C, Jacqz-Aigrain E, Leenhardt A, Roux A, Poirier J M, Jaillon P

Abstract excerpt

Amiodarone has been shown to interact with the nongenetically determined hepatic elimination of several drugs, including phenytoin and digoxin. Its influence on genetically determined metabolic pathways has not been studied in humans. We examined the effects of oral amiodarone therapy on the genetically determined metabolism of isoniazid (N-acetyltransferase), mephenytoin (cytochrome P450MEPH), and...

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Identifiers

PMID: 1914360
DOI: 10.1038/clpt.1991.135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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