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Article

Dextromethorphan phenotyping and haloperidol disposition in schizophrenic patients.

Psychiatry research - 24 Mar 1997

Lane H Y, Hu O Y, Jann M W, Deng H C, Lin H N, Chang W H

Abstract excerpt

This study examined the relationship between the metabolic ratios of dextromethorphan/dextrorphan, haloperidol disposition, and the incidence of extrapyramidal side effects in schizophrenic patients. Eighteen schizophrenic patients were phenotyped with a test dose of dextromethorphan prior to the initiation of haloperidol treatment. The metabolic ratio of dextromethorphan/dextrorphan was determined in each...

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PMID: 9109178
DOI: 10.1016/s0165-1781(96)02999-x

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