Article
Pharmacokinetics and polymorphic oxidation of dextromethorphan in a Japanese population.
Biopharmaceutics & drug disposition - 1 Jul 1996
Nagai N, Kawakubo T, Kaneko F, Ishii M, Shinohara R, Saito Y, Shimamura H, Ohnishi A, Ogata H
Abstract excerpt
The plasma concentration and cumulative urinary excretion over 34 h of dextromethorphan, free and conjugated dextrorphan, and 3-hydroxymorphinan were determined in seven healthy Japanese subjects after oral administration of 30 mg dextromethorphan hydrobromide. Conjugated metabolites were extensi...
Topics
- Administration, Oral
- Adult
- Antitussive Agents
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP2D6
- Dextromethorphan
- Dextrorphan
- Female
- Humans
- Japan
- Male
- Oxidation-Reduction