Article
Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: relationship to the presence of immunoidentified cytochrome P-450IID1.
Clinical pharmacology and therapeutics - 1 Jan 1990
Mortimer O, Persson K, Ladona M G, Spalding D, Zanger U M, Meyer U A, Rane A
Abstract excerpt
We studied the oxidation capacity in liver biopsies of a series of extensive metabolizers (n = 10) and poor metabolizers (n = 2) as identified by in vivo phenotyping with dextromethorphan. Codeine and dextromethorphan were used as probe drugs in vitro. The data were compared with the contents of cytochrome P-450IID1 as quantitated by Western immunoblotting by use of a specific monoclonal antibody (MAb 114/2). The...
Topics
- Antibodies, Monoclonal
- Blotting, Western
- Codeine
- Cytochrome P-450 Enzyme System
- Dextromethorphan
- Humans
- Levorphanol
- Microsomes, Liver
- Morphine
- Oxidoreductases, N-Demethylating