Article
Polymorphism of dextromethorphan metabolism: relationships between phenotype, genotype and response to the administration of encainide in humans.
The Journal of pharmacology and experimental therapeutics - 1 Nov 1992
Funck-Brentano C, Thomas G, Jacqz-Aigrain E, Poirier J M, Simon T, Béréziat G, Jaillon P
Abstract excerpt
The polymorphism of dextromethorphan and encainide metabolism is genetically determined and is related to the activity of hepatic CYP2D6. In order to examine the relations between CYP2D6 phenotype, genotype and the electrocardiographic response to the oral administration of encainide, 110 healthy...
Topics
- Adult
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Dextromethorphan
- Dextrorphan
- Electrocardiography
- Encainide
- Genotype
- Humans
- Mixed Function Oxygenases
- Phenotype