Article
Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation.
Clinical pharmacology and therapeutics - 1 Oct 1996
Jones D R, Gorski J C, Haehner B D, O'Mara E M, Hall S D
Abstract excerpt
Dextromethorphan is used widely in vivo to phenotype the polymorphically expressed cytochrome P450 (CYP) 2D6. Dextromethorphan is N-demethylated in vitro to 3-methoxymorphinan by human CYP3A4/5. We examined whether the dextromethorphan/3-methoxymorphinan urinary metabolic ratio (MR) could be used...
Topics
- Administration, Oral
- Adolescent
- Adult
- Antitussive Agents
- Cross-Over Studies
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
- Dextromethorphan
- Drug Interactions
- Erythromycin
- Female
- Humans
- Male
- Microsomes, Liver
- Middle Aged
- Mixed Function Oxygenases
- Phenotype