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Article

Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation.

Clinical pharmacology and therapeutics - 1 Oct 1996

Jones D R, Gorski J C, Haehner B D, O'Mara E M, Hall S D

Abstract excerpt

Dextromethorphan is used widely in vivo to phenotype the polymorphically expressed cytochrome P450 (CYP) 2D6. Dextromethorphan is N-demethylated in vitro to 3-methoxymorphinan by human CYP3A4/5. We examined whether the dextromethorphan/3-methoxymorphinan urinary metabolic ratio (MR) could be used as an in vivo probe of CYP3A. Urinary excretion of 3-methoxymorphinan was excretion rate-limited in extensive...

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Identifiers

PMID: 8873685
DOI: 10.1016/S0009-9236(96)90194-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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