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Article

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes.

Clinical pharmacology and therapeutics - 1 Oct 1992

Breyer-Pfaff U, Pfandl B, Nill K, Nusser E, Monney C, Jonzier-Perey M, Baettig D, Baumann P

Abstract excerpt

In 26 hospitalized patients with depression, a combined pharmacogenetic test with dextromethorphan, a substrate of cytochrome P450IID6, and mephenytoin, the S-form of which is hydroxylated by a P450IIC isozyme, was carried out before amitriptyline therapy. Metabolites were determined in 24-hour urine samples collected on treatment day 8, and the contributions of individual compounds, including the four isomers of...

Topics

Adult
Amitriptyline
Cytochrome P-450 Enzyme System
Dextromethorphan
Female
Humans
Isoenzymes
Male
Mephenytoin
Metabolic Clearance Rate
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nortriptyline

Phenotype

Regression Analysis

Stereoisomerism

Source

Identifiers

PMID: 1424408
DOI: 10.1038/clpt.1992.155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1424408-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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