Article
Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism.
British journal of clinical pharmacology - 1 Apr 1990
Guttendorf R J, Britto M, Blouin R A, Foster T S, John W, Pittman K A, Wedlund P J
Abstract excerpt
1. The phenotyping parameters for dextromethorphan and mephenytoin were assessed in 48 normal male volunteers following administration of each metabolic probe drug on separate occasions and together according to a randomized 3-way crossover design. 2. Neither the urinary S-/R-mephenytoin ratio nor the dextromethorphan metabolic ratio were altered significantly by coadministration of the probe drugs. 3....
Topics
- Adolescent
- Adult
- Aged
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Dextromethorphan
- Drug Interactions
- Humans
- Hydantoins
- Levorphanol