Article
Characterization of the defect in a variant of HL-60 promyelocytic leukemia cells with reduced transferrin receptor expression.
Somatic cell and molecular genetics - 1 Jan 1992
Ishiguro K, Ho P T, Sartorelli A C
Abstract excerpt
The mechanism by which a clone of HL-60 human promyelocytic leukemia cells designated Tf-Gel-1 expresses reduced levels of the transferrin receptor (TfR) was investigated. Tf-Gel-1 was developed by continuous exposure of HL-60 cells to human iron-saturated transferrin covalently linked to the plant toxin gelonin (Tf-Gel); this variant was five- to sixfold more resistant to Tf-Gel than parental HL-60 cells. The...
Topics
- Antigens, Surface
- Carbohydrates
- Clone Cells
- Drug Resistance
- Gene Expression Regulation, Neoplastic
- Genetic Variation
- Humans
- Lectins
- Leukemia, Promyelocytic, Acute
- Plant Proteins
- Protein Synthesis Inhibitors