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Article

HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation.

Nucleic acids research - 1 Nov 1999

Bianchi L, Tacchini L, Cairo G

Abstract excerpt

Treatment with iron chelators mimics hypoxic induction of the hypoxia inducible factor (HIF-1) which activates transcription by binding to hypoxia responsive elements (HRE). We investigated whether HIF-1 is involved in transcriptional activation of the transferrin receptor (TfR), a membrane protein which mediates cellular iron uptake, in response to iron deprivation. The transcription rate of the TfR gene in...

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Identifiers

PMID: 10518614
DOI: 10.1093/nar/27.21.4223
PMCID: PMC148697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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