Article
Membrane glycoprotein changes associated with anthracycline resistance in HL-60 cells.
Cancer chemotherapy and pharmacology - 1 Jan 1991
Gervasoni J E, Taub R N, Rosado M, Krishna S, Stewart V J, Knowles D M, Bhalla K, Ross D D, Baker M A, Lutzky J
Abstract excerpt
The glycoproteins on the surface of HL-60/S wild-type, drug-sensitive human leukemia cells and HL-60/AR anthracycline-resistant cells which do not overexpress the P-glycoprotein, were characterized by labeling with [35S]-methionine, NaB[3H4], phosphorus 32, or sodium iodide I 125. HL-60/S and HL-60/AR cell lysates and membrane fractions tagged with [35S]-methionine or phosphorus 32 showed no significant...
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