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Article

Membrane glycoprotein changes associated with anthracycline resistance in HL-60 cells.

Cancer chemotherapy and pharmacology - 1 Jan 1991

Gervasoni J E, Taub R N, Rosado M, Krishna S, Stewart V J, Knowles D M, Bhalla K, Ross D D, Baker M A, Lutzky J

Abstract excerpt

The glycoproteins on the surface of HL-60/S wild-type, drug-sensitive human leukemia cells and HL-60/AR anthracycline-resistant cells which do not overexpress the P-glycoprotein, were characterized by labeling with [35S]-methionine, NaB[3H4], phosphorus 32, or sodium iodide I 125. HL-60/S and HL-60/AR cell lysates and membrane fractions tagged with [35S]-methionine or phosphorus 32 showed no significant...

Topics

Antibiotics, Antineoplastic
Autoradiography
Cell Line
Culture Techniques
Drug Resistance
Electrophoresis, Polyacrylamide Gel
Epitopes
Glycosylation
Humans
Leukemia, Myeloid
Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Tetradecanoylphorbol Acetate

Tretinoin

Tunicamycin

Source

Identifiers

PMID: 1711935
DOI: 10.1007/BF00689695

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1711935-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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