Article
Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14.
Human mutation - 1 Nov 2004
Perotti Daniela, De Vecchi Giovanna, Testi Maria A, Lualdi Elena, Modena Piergiorgio, Mondini Patrizia, Ravagnani Fernando, Collini Paola, Di Renzo Francesca, Spreafico Filippo, Terenziani Monica, Sozzi Gabriella, Fossati-Bellani Franca, Radice Paolo
Abstract excerpt
Wilms tumor (WT) is a kidney malignancy of childhood characterized by highly heterogeneous genetic alterations. We previously reported the molecular and cytogenetic characterization of a WT (Case 30) carrying an interstitial deletion in chromosome 7p14 between markers D7S555 and D7S668. Loss of heterozygosity (LOH) analyses had revealed that this same region was lost in 8 out of 38 examined WTs, suggesting that...
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