Article
p57K1P2 is expressed in Wilms' tumor with LOH of 11p15.5.
Genes, chromosomes & cancer - 1 Sept 1996
Overall M L, Spencer J, Bakker M, Dziadek M, Smith P J
Abstract excerpt
p57KIP2 is a cyclin-dependent kinase inhibitor that maps to human chromosome band 11p15.5, placing it in a genomically imprinted region that has been implicated in the etiology of Wilms' tumor and in the Beckwith-Wiedemann syndrome. Recent analysis of p57KIP2 expression in the mouse has determine...
Topics
- Alleles
- Animals
- Blotting, Southern
- Chromosome Deletion
- Chromosomes, Human, Pair 11
- Cyclin-Dependent Kinase Inhibitor p57
- Cyclin-Dependent Kinases
- Gene Expression
- Genes, Wilms Tumor
- Heterozygote
- Humans
- Kidney Neoplasms
- Mice
- Nuclear Proteins
- Polymerase Chain Reaction
- Wilms Tumor