Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p57K1P2 is expressed in Wilms' tumor with LOH of 11p15.5.

Genes, chromosomes & cancer - 1 Sept 1996

Overall M L, Spencer J, Bakker M, Dziadek M, Smith P J

Abstract excerpt

p57KIP2 is a cyclin-dependent kinase inhibitor that maps to human chromosome band 11p15.5, placing it in a genomically imprinted region that has been implicated in the etiology of Wilms' tumor and in the Beckwith-Wiedemann syndrome. Recent analysis of p57KIP2 expression in the mouse has determined that this gene is exclusively expressed from the maternal allele. It has been suggested that p57KIP2 is the WT2 tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Blotting, Southern
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Heterozygote

Share to Nuclear Proteins

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 8889507
DOI: 10.1002/(SICI)1098-2264(199609)17:1<56::AID-GCC8>3.0.CO;2-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p57K1P2 is expressed in Wilms' tumor with LOH of 11p15.5.PMID 8889507Read ↗

Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.Semantic proximity Read ↗

An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5.Semantic proximity Read ↗

Coding mutations in p57KIP2 are present in some cases of Beckwith-Wiedemann syndrome but are rare or absent in Wilms tumors.Semantic proximity Read ↗

Human p57(KIP2) defines a new imprinted domain on chromosome 11p but is not a tumour suppressor gene in Wilms tumour.Semantic proximity Read ↗

Genomic imprinting of human p57KIP2 and its reduced expression in Wilms' tumors.Semantic proximity Read ↗

Assessment of p57(KIP2) gene mutation in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Multiple genetic abnormalities of 11p15 in Wilms' tumor.Semantic proximity Read ↗

Comparative reverse transcription-polymerase chain reaction and in situ hybridization analyses of human imprinted p57KIP2 and insulin-like growth factor 2 gene transcripts in fetal kidney and Wilms' tumors using archival tissue.Semantic proximity Read ↗

Functional analysis of the p57KIP2 gene mutation in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Disruption of imprinted genes at chromosome region 11p15.5 in paediatric rhabdomyosarcoma.Semantic proximity Read ↗

Chromosome 11p15.5 regional imprinting: comparative analysis of KIP2 and H19 in human tissues and Wilms' tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.