Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors.

Journal of pediatric hematology/oncology - 1 Dec 2006

Di Renzo Francesca, Doneda Luisa, Menegola Elena, Sardella Michele, De Vecchi Giovanna, Collini Paola, Spreafico Filippo, Fossati-Bellani Franca, Giavini Erminio, Radice Paolo, Perotti Daniela

Abstract excerpt

We have previously suggested the transcription factor gene POU6F2 as a novel tumor suppressor involved in Wilms tumor (WT) predisposition. Since WT arises from pluripotent embryonic renal precursors, in this study we analyzed the expression of the murine homolog Pou6f2 during kidney embryogenesis and compared it to that of Wt1, the homolog of WT1, a known WT related gene involved in mesenchyme to epithelium...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Developmental
Share to Kidney

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesoderm

Share to Neoplastic Stem Cells

Share to Organogenesis

Share to POU Domain Factors

Share to Wilms Tumor

Share to WT1 Proteins

Source

Identifiers

PMID: 17164647
DOI: 10.1097/MPH.0b013e31802d3e65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors.PMID 17164647Read ↗

Wilms' tumor gene 1: lessons from the interface between kidney development and cancer.Semantic proximity Read ↗

Towards an understanding of kidney diseases associated with WT1 mutations.Semantic proximity Read ↗

WT1 and kidney progenitor cellsSemantic proximity Read ↗

Exploring the Multifaceted Role of WT1 in Kidney Development and DiseaseSemantic proximity Read ↗

Expression of WT1 during normal human kidney developmentSemantic proximity Read ↗

The tumor suppressor WT1 drives progenitor cell progression and epithelialization to prevent Wilms tumorigenesis in human kidney organoidsSemantic proximity Read ↗

SIX1 protein expression selectively identifies blastemal elements in Wilms tumorSemantic proximity Read ↗

Temporal blastemal cell gene expression analysis in the kidney reveals new Wnt and related signaling pathway genes to be essential for Wilms' tumor onsetSemantic proximity Read ↗

Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice.Semantic proximity Read ↗

The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressorSemantic proximity Read ↗

Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development.Semantic proximity Read ↗

Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.