Article
Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2010
Williams Richard D, Al-Saadi Reem, Chagtai Tasnim, Popov Sergey, Messahel Boo, Sebire Neil, Gessler Manfred, Wegert Jenny, Graf Norbert, Leuschner Ivo, Hubank Mike, Jones Chris, Vujanic Gordan, Pritchard-Jones Kathy
Abstract excerpt
PURPOSE: Wilms' tumor (WT), the most common pediatric renal malignancy, is associated with mutations in several well-characterized genes, most notably WT1, CTNNB1, WTX, and TP53. However, the majority of cases do not harbor mutations in these genes. We hypothesized that additional drivers of tumor behavior would be contained within areas of consistent genomic copy number change, especially those associated with...
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