Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotype exclusion and receptor editing: irreconcilable differences?

Seminars in immunology - 1 Jun 2002

Nemazee David, Mårtensson Annica, Verkoczy Laurent

Abstract excerpt

Features of antibody genes and their regulation hinder two properties thought to be critical for clonal selection: haplotype exclusion and receptor diversity. These properties include: (1) the retention of multiple independent L-chain isotypes, which compounds the problem of allelic exclusion with one of isotype exclusion; (2) the process of receptor editing, in which recombination continues in cells already...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Gene Rearrangement, B-Lymphocyte
Share to Haplotypes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immune Tolerance

Share to Models, Genetic

Share to Models, Immunological

Share to Receptors, Antigen, B-Cell

Share to RNA Editing

Source

Identifiers

PMID: 12160646
DOI: 10.1016/s1044-5323(02)00042-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotype exclusion and receptor editing: irreconcilable differences?PMID 12160646Read ↗

B cell receptor editing in tolerance and autoimmunitySemantic proximity Read ↗

Receptor selection in B and T lymphocytes.Semantic proximity Read ↗

The lingering enigma of the allelic exclusion mechanism.Semantic proximity Read ↗

Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire.Semantic proximity Read ↗

Models for antigen receptor gene rearrangement. I. Biased receptor editing in B cells: implications for allelic exclusion.Semantic proximity Read ↗

A stepwise epigenetic process controls immunoglobulin allelic exclusion.Semantic proximity Read ↗

Allelic exclusion of immunoglobulin genes: models and mechanisms.Semantic proximity Read ↗

Antigen receptor allelic exclusion: an update and reappraisal.Semantic proximity Read ↗

Immunoglobulin Light Chain Gene Rearrangements, Receptor Editing and the Development of a Self-Tolerant Antibody RepertoireSemantic proximity Read ↗

Choreography of Ig allelic exclusion.Semantic proximity Read ↗

Long-Range Control of V(D)J Recombination & Allelic Exclusion: Modeling Views.Semantic proximity Read ↗

Igkappa allelic inclusion is a consequence of receptor editing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.