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Article

The lingering enigma of the allelic exclusion mechanism.

Cell - 3 Sept 2004

Mostoslavsky Raul, Alt Frederick W, Rajewsky Klaus

Abstract excerpt

B lymphocytes produce diverse antibody specificities by "randomly" assembling antibody genes from germline segments. Yet, though each B lymphocyte has multiple allelic loci for the different antibody chains, each clonally derived mature B lymphocyte expresses a single species of antibody with a unique specificity via a process termed allelic exclusion. Despite some progress, the precise mechanism of allelic...

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Identifiers

PMID: 15339659
DOI: 10.1016/j.cell.2004.08.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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