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Article

KDEL tagging: a method for generating dominant-negative inhibitors of the secretion of TGF-beta superfamily proteins.

The International journal of developmental biology - 1 Jan 2012

Matsukawa Shinya, Moriyama Yuki, Hayata Tadayoshi, Sasaki Haruka, Ito Yuzuru, Asashima Makoto, Kuroda Hiroki

Abstract excerpt

Most endoplasmic reticulum (ER)-retained proteins contain a carboxy-terminal signal sequence called the ER retention signal motif such as the Lys-Asp-Glu-Leu (KDEL) motif. Using this molecular mechanism, we developed a new dominant-negative assay, designated the KDEL-tag trap assay, to negatively regulate secretion of disulfide bond-dependent protein dimers, as typified by TGF-beta superfamily proteins. First, we...

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Source

Identifiers

PMID: 22811269
DOI: 10.1387/ijdb.123514sm

Genes

BMP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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