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Article

Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development

31 Mar 2011

Abstract excerpt

Low-density lipoprotein receptor-related protein 2 (LRP2) is a multifunctional cell surface receptor conserved from nematodes to humans. In mammals, it acts as regulator of sonic hedgehog and bone morphogenetic protein pathways in patterning of the embryonic forebrain and as a clearance receptor in the adult kidney. Little is known about activities of this LRP in other phyla. Here, we extend the functional...

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PMID: 21455927
DOI: 10.1002/dvdy.22624

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