Article
Plasticity of acetylcholine receptor gating motions via rate-energy relationships.
Biophysical journal - 1 Nov 2005
Mitra Ananya, Tascione Richard, Auerbach Anthony, Licht Stuart
Abstract excerpt
Like other protein conformational changes, ion channel gating requires the protein to achieve a high-energy transition-state structure. It is not known whether ion channel gating takes place on a broad energy landscape on which many alternative transition state structures are accessible, or on a narrow energy landscape where only a few transition-state structures are possible. To address this question, we...
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